Inhibition of the defensive mechanism of bacteria against many antibiotics from the antibiotics list, drug efflux pumps, can initiate the mutations that result in antibiotic resistance in low affinity drug binding to target molecules in the cell. By researchers from Uppsala University, this claim has been clearly presented in a new study that gives important information on how to delay the antibiotic resistance development in bacteria against a large number of antibiotics from long antibiotics list.
Treating bacterial infections by antibiotics as drugs in the post second world war years, was viewed as a modernized medicine and has treated health problems on a large scale. Nowadays, the increasing antibiotic resistance of bacteria to many antibiotics in the common antibiotic list has worn out the resources of highly necessary antibiotic drugs.
All of the antibiotics from the antibiotics list fight against bacteria which do not have antibiotic resistance, by attacking their molecules that enable them to survive and they defend themselves by using "drug efflux pumps" against antibiotics or by mutations by lowering the number of molecules available for all the antibiotics from the antibiotic list to bind and destroy most of the bacteria. Due to these changes in the molecular structures the bacteria gets antibiotic resistance and fight against many antibiotics in the antibiotic list.
Proceedings of the National Academy of Sciences journal have issued a new study which was carried out by US. Professor Måns Ehrenberg's research team at Uppsala University has clearly showed in their experiments and explained theoretically how the inhibition of the bacteria drug efflux pumps can entirely cover the effects of the antibiotic resistance bacteria to reduce the binding of antibiotics to target molecules. Mutations have various effects and they are completely undetectable when the efflux pumps cannot efficiently and quickly remove the antibiotic in concentration to the reduction of antibiotics during cell division and/or cell growth.
The detailed study presents vital information on preventing and delaying antibiotics resistance in bacteria against the antibiotics from the long antibiotics list.